Silencing KRAS
نویسندگان
چکیده
منابع مشابه
Therapeutic silencing of KRAS using systemically delivered siRNAs.
Despite being among the most common oncogenes in human cancer, to date, there are no effective clinical options for inhibiting KRAS activity. We investigated whether systemically delivered KRAS siRNAs have therapeutic potential in KRAS-mutated cancer models. We identified KRAS siRNA sequences with notable potency in knocking down KRAS expression. Using lung and colon adenocarcinoma cell lines, ...
متن کاملSimultaneous gene silencing of KRAS and anti-apoptotic genes as a multitarget therapy.
Pancreatic cancer is one of the most lethal tumor types worldwide and an effective therapy is still elusive. Targeted therapy focused against a specific alteration is by definition unable to attack broad pathway signaling modification. Tumor heterogeneity will render targeted therapies ineffective based on the regrowth of cancer cell sub-clones. Therefore multimodal therapy strategies, targetin...
متن کاملKRAS-driven miR-29b expression is required for tumor suppressor gene silencing
KRAS activation drives DNA methylation and silencing of specific tumor suppressor genes (TSGs). We previously showed that the ERK pathway induces transcriptional repression of TET1, which results in conversion of TSG promoters from a hydroxymethylated, active state to a hypermethylated and silenced state. Here we identified miR-29b as a KRAS-induced molecule that represses TET1 expression. In K...
متن کاملA KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype
Approximately 70% of KRAS-positive colorectal cancers (CRCs) have a CpG island methylator phenotype (CIMP) characterized by aberrant DNA hypermethylation and transcriptional silencing of many genes. The factors involved in, and the mechanistic basis of, CIMP is not understood. Among the CIMP genes are the tumor suppressors p14(ARF), p15(INK4B), and p16(INK4A), encoded by the INK4-ARF locus. In ...
متن کاملTRANSLATIONAL PHYSIOLOGY FXR silencing in human colon cancer by DNA methylation and KRAS signaling
Ann M. Bailey, Le Zhan, Dipen Maru, Imad Shureiqi, Curtis R. Pickering, Galina Kiriakova, Julie Izzo, Nan He, Caimiao Wei, Veerabhadran Baladandayuthapani, Han Liang, Scott Kopetz, Garth Powis, and Grace L. Guo Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2014
ISSN: 1945-3477
DOI: 10.1038/scibx.2014.4